Overview

The main objective of phase III was to develop HAp based coatings co-doped with Mg and Zn that will ensure at the same time an enhanced bioactivity, biodegradation, biocompatibility and bactericidal effect. The coatings were obtained under similar conditions as the ones obtained in phase II, and two types of HAp coatings co-doped with Mg and Zn (codified with HMZ1 and HMZ2) were characterized and tested. Compared with pure unmodified Ti, the results obtained from the characterization and testing of the HMZ coatings, showed that both coatings have enhanced the behavior of the unmodified Ti and could be successfully used in medical applications.
After overviewing all the results obtained in the current project, and the correlation were made, one coating of all was selected, namely HMZ1, and an experimental model was made.

In order to validate the surface modification techniques employed in the 3B-CoatED project, an experimental model that consisted of a Ti based dental implant, commercially available, and which wasn’t previously modified and had an unaltered surface, was exposed to anodic oxidation in order to obtain a nanostructured surface, after which was coated with the HMZ1 coating by applying the pulsed galvanostatic technique. Both surface modifications methods were successfully applied and implemented in our laboratory on the dental implant, indicating the feasibility of the proposed techniques.

Papers published in ISI journals

• Published

1. Influence of Magnesium Content on the Physico-Chemical Properties of Hydroxyapatite Electrochemically Deposited on a Nanostructured Titanium Surface, Cosmin M. Cotrut, Elena Ungureanu, Ionut C. Ionescu, Raluca I. Zamfir, Adrian E. Kiss, Anca C. Parau, Alina Vladescu, Diana M. Vranceanu, Adriana Saceleanu, Coatings, 2022, Vol. 12, Iss. 8, Article Number 1097, F.I.₂₀₂₂ = 3.236 (Q2)

2. Electrochemical biofunctionalization of titanium through growth of TiO2 nanotubes and deposition of Zn doped hydroxyapatite, Diana M. Vranceanu, Elena Ungureanu, Ionut Cornel Ionescu, Anca Parau, Adrian Kiss, Alina Vladescu, Cosmin M. Cotrut, Coatings, 2022, Vol. 12, Iss. 1, Article Number 69, F.I.₂₀₂₂ = 3,236 (Q2)

3. Effect of doping element and electrolyte’s pH on the properties of hydroxyapatite coatings obtained by pulsed galvanostatic technique, Elena Ungureanu, Diana M Vranceanu, Alina Vladescu, Anca Parau, Mihail Tarcolea, Cosmin M. Cotrut, Coatings, 2021, Vol. 11, Iss. 12, Article Number 1522, F.I.₂₀₂₂ = 3.236 (Q2)

4. Evaluation of surface modification techniques on the ability of apatite formation and corrosion behavior in synthetic body fluid: an in vitro study, C.M. Cotrut, I.C. Ionescu, E. Ungureanu, A. Berbecaru, R.I. Zamfir, A. Vladescu, D.M. Vranceanu, Surfaces and Interfaces, 2021, Vol. 22, Article Number 100866, F.I.₂₀₂₂ = 6.137 (Q1)

Papers presented at international conference

• Invited presentations

1. Surface bioactivation of metallic materials through electrochemical techniques, C.M. Cotrut, The 9th International Conference ”Biomaterials, Tissue Engineering & Medical Devices”, BiomMedD’2022, 20-22 July 2022, Bucharest, Romania.

• Oral presentations

1. Biofunctionalization of titanium with titania nanotubes and doped hydroxyapatite-based coatings, D.M. Vranceanu, I.C. Ionescu, E. Ungureanu, A.C. Parau, A. Vladescu., C.M. Cotrut, 9th International Conference “Biomaterials, Tissue Engineering & Medical Devices” BIOMMEDD’2022, July 20-22, 2022, Bucharest, Romania.

• Posters presentations

1.Influence of Mg and Zn content on the properties of hydroxyapatite based coatings, D. M. Vranceanu, I.C. Ionescu, E. Ungureanu, A. Kiss, A.C. Parau, A. Vladescu and C.M. Cotrut, The 6th International Conference New Trends on Sensing - Monitoring - Telediagnosis for Life Sciences NT-SMT-LS 2022, September 8 – 10, 2022, Brasov, Romania.

2. In vitro evaluation of doped hydroxyapatite coatings electrochemically deposited on titanium nanostructured surface, , D.M. Vranceanu, I.C. Ionescu, E. Ungureanu, A.C. Parau, R.I. Zamfir, I. Titorencu, M. Badea, C. Adochitei, S. Costinas, M. Iodomir, A. Vladescu and C.M. Cotrut, The 6th International Conference New Trends on Sensing - Monitoring - Telediagnosis for Life Sciences NT-SMT-LS 2022, September 8 – 10, 2022, Brasov, Romania.

3. The influence of electrolyte’s pH and doping element on the properties of hydroxyapatite coatings obtained by electrochemical deposition, E. Ungureanu, D.M. Vranceanu, A.C. Parau, A. Vladescu, C.M. Cotrut, The 9th International Conference ” Biomaterials, Tissue Engineering & Medical Devices”, BiomMedD’2022, 20-22 July 2022, Bucharest, Romania.

4. Physico-chemical properties and in vitro behavior of Zn doped HAp based coatings deposited on nanostructured surface, D. M. Vranceanu, I.C. Ionescu, E. Ungureanu, A. Kiss, G.A. Juravlea, R.I. Zamfir, I. Titorencu, A. Vladescu and C.M. Cotrut, European Materials Research Society – Spring Meeting (EMRS2022 – Spring Meeting Virtual Conference), 30.05. –03.06.2022, Functional materials, Symposiom O - Nano-engineered coatings and thin films: from design to applications.

• Other results

• Public defense of the Doctoral Thesis entitled Studies and research on improving the osseointegration properties of titanium through electrochemical techniques – PhD Candidate Ionut Cornel IONESCU, held in University POLITEHNICA of Bucharest on the 14th October 2022.